Genesis
Genesis is a Boss artifact that gives you a choice of 1 of 2 artifacts 3 times on pickup, but also gives you 3 Genesis Canisters.
Strategy
Given how many common artifacts are quite useful to a run, go ahead and give this a try - you'll rarely be disappointed. This is particularly true if you're hunting for a particular artifact to hit the next gear, such as Stun Calibrator, Drone Piercer on the Jupiter, Recalibrator or Safety Lock (on Max) for an infinite combo. Even otherwise, there's several generally useful hits like Jet Thrusters, Overcharger, Overclocked Generator...
The Genesis Canisters often aren't that big of a deal thanks to them being Single Use - you just need to find one fight to stall in and they aren't a problem for the rest of the run. CCD-62 “Cicada” Drone Mk2 and CCD-62 “Cicada” Drone Mk3, the first fights of Sapphire Cluster and Void's Cradle respectively, are quite stallable, especially with good Evade, giving you ample opportunity to deal with them. At worst, you may have to gambit a bit of hull to get rid of them if you aren't as evasively inclined. (Don't procrastinate getting rid of them, however, as the draw loss will hurt you over time and in tougher fights!)